Szczegóły publikacji
Opis bibliograficzny
3D-printed PCL scaffolds: optimising material selection for specific bone regeneration applications / Izabella Rajzer, Renata Novotna, Anna Kurowska, Jarosław Janusz, Janusz Fabia, Adam Jabłoński, Wojciech PIEKARCZYK, Oscar Castano, Magdalena ZIĄBKA, Jana Frankova // Journal of Materials Science: Materials in Medicine ; ISSN 0957-4530 . — 2026 — vol. 37 iss. 1 art. no. 76, s. 1–16. — Bibliogr. s. 15–16, Abstr. — Publikacja dostępna online od: 2026-04-24
Autorzy (10)
- Rajzer Izabella
- Novotna Renata
- Kurowska Anna
- Janusz Jarosław
- Fabia Janusz
- Jabłoński Adam
- AGHPiekarczyk Wojciech
- Castano Oscar
- AGHZiąbka Magdalena
- Frankova Jana
Dane bibliometryczne
| ID BaDAP | 168487 |
|---|---|
| Data dodania do BaDAP | 2026-06-29 |
| Tekst źródłowy | URL |
| DOI | 10.1007/s10856-026-07047-w |
| Rok publikacji | 2026 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Journal of Materials Science-Materials in Medicine |
Abstract
Significant clinical challenges are posed by large bone defects, necessitating the use of scaffolds that combine mechanical stability with osteoinductive properties. While polycaprolactone (PCL) lends itself well to 3D printing, its limited bioactivity means it needs to be modified with bioactive additives. Various additives have been proposed to enhance PCL scaffolds, but a systematic comparative evaluation of their mechanical and biological effects is lacking. This hinders the optimal selection of materials for specific applications. In this study, we compared the effects of four additives—silver nanoparticles (AgNPs), osteogenon (OST), zinc oxide (ZnO) and vitroceramic calcium phosphate (CaPNPs)—when incorporated at a concentration of 0.5 wt% into 3D-printed PCL scaffolds. We comprehensively evaluated the mechanical properties, thermal characteristics, and osteoblast biocompatibility using tensile testing, differential scanning calorimetry, and SaOS-2 cell culture assays (MTT test, activity of alkaline phosphatase, production of collagen I and fluorescent staining with acridine orange or phalloidin). ZnO modification significantly enhanced the mechanical properties (834% strain at break versus 658% for pure PCL and an increased Young’s modulus), as well as supporting cell viability (87 and 85%). Meanwhile, CaPNPs demonstrated the highest level of early-stage cell viability (103% after 24 h), although this was not statistically significant. All additives exhibited non-cytotoxic profiles with >80% cell viability and demonstrated time-dependent increases in alkaline phosphatase activity, but further evaluation for clinical application is essential. These findings provide evidence-based guidance for selecting PCL scaffold additives based on specific application requirements: ZnO is optimal for mechanically demanding applications, while CaPNPs could be optimal for facilitating rapid cell integration.
