Szczegóły publikacji
Opis bibliograficzny
Highly swellable collagen-chitosan magnetic hybrid hydrogels for bone tissue engineering applications / Adriana GILARSKA, Sylwia FIEJDASZ, Iwona HABINA-SKRZYNIARZ, Artur KRZYŻAK, Joanna Dulińska-Litewka, Dorota Gil, Agnieszka RADZISZEWSKA, Maria Nowakowska, Czesław KAPUSTA // Sustainable Materials and Technologies ; ISSN 2214-9929 . — 2026 — vol. 48 art. no. e02056, s. 1–14. — Bibliogr. s. 12–14, Abstr. — Publikacja dostępna online od: 2026-05-07
Autorzy (9)
- AGHGilarska Adriana
- AGHFiejdasz Sylwia
- AGHHabina-Skrzyniarz Iwona
- AGHKrzyżak Artur Tadeusz
- Dulińska-Litewka Joanna
- Gil Dorota
- AGHRadziszewska Agnieszka
- Nowakowska Maria
- AGHKapusta Czesław
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 168035 |
|---|---|
| Data dodania do BaDAP | 2026-07-03 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.susmat.2026.e02056 |
| Rok publikacji | 2026 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Sustainable Materials and Technologies |
Abstract
The paper reports on highly swellable hybrid magnetic materials based on natural-origin polymers containing superparamagnetic iron oxide nanoparticles (SPIONs), as potential scaffolds for bone tissue engineering supported by non-invasive static magnetic fields (SMF). Hydrogel matrices used were designed and optimized to be easily moldable and, thus, able to adapt to specific shape of a defect. Non-invasive NMR methods were applied to study the interaction of water with the hydrogel network, as one of the key aspects of materials for biomedical applications. Swelling studies have shown that magnetic hydrogels have great swelling capacity (swelling ratio ranged from 10,000 to 13,000%) and high water uptake with the degradation being adjustable, depending on the hydrogel composition. The surface is characterized by wettability with a contact angle in the range of 82–89 degrees for all the hydrogels tested. Preliminary biological evaluation confirmed that SPIONs present in hybrid materials do not have negative influence on osteoblast-like cells (viability and adhesion) and promote cell growth after 3 days of cell culture. Experiments conducted in the presence of a static magnetic field (SMF) showed that both SMF and the incorporation of SPIONs into the hydrogel matrix affect cell viability and proliferation, accompanied by changes in protein expression involved in cells proliferation and differentiation, especially after 7 days of incubation. The number of cells varied over the study period depending on the intensity of the applied magnetic field and the presence of magnetic nanoparticles embedded in the hydrogel structure. The materials developed support the concept of sustainability owing to their biocompatible, swellable and degradable composition. The use of a non-invasive NMR method allowed a thorough analysis of their structure and optimal adjustment of the material composition. A potential use of magnetic fields of a safe strength for non-invasive support of tissue regeneration was also investigated. © 2026 The Authors.
