Szczegóły publikacji
Opis bibliograficzny
Tailoring alkyl modification patterns in hyaluronic acid derivatives serving as carriers for enhanced kartogenin delivery and chondrogenic responses / Magdalena WYTRWAŁ, Sylwia RZEPA, Ewa Ocłoń, Mirosław Kucharski, Ewelina BIK, Katarzyna FILIPEK, Wendy Koevoet, Gerjo J. V. M. van Osch, Szczepan Zapotoczny // International Journal of Biological Macromolecules ; ISSN 0141-8130 . — 2026 — vol. 359 art. no. 151809, s. 1–14. — Bibliogr. s. 13–14, Abstr. — Publikacja dostępna online od: 2026-04-03
Autorzy (9)
- AGHWytrwał Magdalena
- AGHRzepa Sylwia
- Ocłoń Ewa
- Kucharski Mirosław
- AGHBik Ewelina
- AGHFilipek Katarzyna
- Koevoet Wendy
- van Osch Gerjo J. V. M.
- Zapotoczny Szczepan
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 167026 |
|---|---|
| Data dodania do BaDAP | 2026-04-27 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.ijbiomac.2026.151809 |
| Rok publikacji | 2026 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Biological Macromolecules |
Abstract
AbstractCartilage diseases often worsen with age and require orthopedic treatment. To reduce the need for surgery, developing new methods and biomaterials to stimulate and support cartilage regeneration is essential. Among the most promising options are drug delivery systems based on hyaluronic acid (HA), a natural component of the extracellular matrix, known for its biocompatibility, biodegradability, and adjustable chemical modification. In this study, we systematically tailored alkyl modification patterns in HA by introducing alkyl chains of varying lengths and degrees of substitution. Following comprehensive physicochemical characterization, the resulting amphiphilic derivatives formed polyelectrolyte aggregates suitable for controlled delivery of bioactive molecules. Kartogenin (KGN), a small, moderately hydrophobic molecule with chondroprotective effects, was used as a model drug to test the system's potential. The engineered HA derivatives efficiently encapsulated KGN, and specific formulations promoted chondrogenesis in both 2D and 3D cultures by upregulating key chondrogenic markers. These findings highlight the importance of precise alkyl pattern design in modulating HA-based carrier behavior and pave the way for further optimization, including refined substitution strategies, ligand conjugation approaches, and expanded biocompatibility studies toward future in vivo applications.
