Szczegóły publikacji
Opis bibliograficzny
Anticancer activity of the new manganese(II), iron(II), nickel(II), copper(II), and zinc(II) complexes based on 1,2,4-triazoline-3-thione derivative / Agnieszka Czylkowska, Suneel Lanka, Bartłomiej Rogalewicz, Anita Raducka, Ewelina Fornal, Magdalena Iwan, Joanna Kubik, Agnieszka Korga-Plewko, Ewelina Humeniuk, Marcin Świątkowski, Monika Pitucha, Anna Gajda, Aleksandra Lis, Paweł Szymański, Marek SMOLUCH, Andrzej Żarczyński, Aneta Drabińska, Bruno Cury Camargo, Jacek Szczytko // Journal of Trace Elements in Medicine and Biology ; ISSN 0946-672X . — 2025 — vol. 92 art. no. 127786, s. 1–19. — Bibliogr. s. 17–19, Abstr. — Publikacja dostępna online od: 2025-10-23
Autorzy (19)
- Czylkowska Agnieszka
- Lanka Suneel
- Rogalewicz Bartłomiej
- Raducka Anita
- Fornal Ewelina
- Iwan Magdalena
- Kubik Joanna
- Korga-Plewko Agnieszka
- Humeniuk Ewelina
- Świątkowski Marcin
- Pitucha Monika
- Gajda Anna
- Lis Aleksandra
- Szymański Paweł
- AGHSmoluch Marek
- Żarczyński Andrzej
- Drabińska Aneta
- Camargo Bruno
- Szczytko Jacek
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 164608 |
|---|---|
| Data dodania do BaDAP | 2025-12-16 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.jtemb.2025.127786 |
| Rok publikacji | 2025 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Trace Elements in Medicine and Biology |
Abstract
In this study, we report the anticancer evaluation, synthesis, and characterization of a novel organic ligand, 4-butyl-5-((1-methyl-1H-pyrrol-2-yl)methyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione and its five metal complexes based on Mn(II), Fe(II), Ni(II), Cu(II), and Zn(II) ions. All compounds were analyzed using elemental analysis, NMR and FTIR spectroscopies, magnetic measurements, ESR, and thermogravimetric analysis. Their antioxidant properties were evaluated using the ABTS and DPPH assays, and the anticancer activity was studied in silico via molecular docking and in vitro against a panel of cancer cell lines. Notably, the Fe(II), Ni(II), and Cu(II) complexes exhibited potent anticancer activity, with IC50 values of 40.66, 45.95, and 26.51 µM against MDA-MB-231 cells. Their mechanism of action was further investigated through gene expression analysis, cell cycle analysis, apoptosis detection, thiol level evaluation, and DNA damage assessment. The results revealed that Ni(II) and Cu(II) complexes are significantly cytotoxic, while the Fe(II) complex acts as a potent cytostatic agent. Importantly, all compounds demonstrated lower activity toward normal cells than the tested cancer cells.
