Szczegóły publikacji
Opis bibliograficzny
Metabolomic endophenotypes based on oxo-eicosatetraenoic acids in patients with aspirin-exacerbated respiratory disease / Piotr Szatkowski, Adam Stępień, Adam ĆMIEL, Radosław Kacorzyk, Gabriela Trąd-Wójcik, Ewelina Gacek, Lucyna Mastalerz // Journal of Allergy and Clinical Immunology ; ISSN 0091-6749. — 2025 — vol. 156 iss. 3, s. 616-626. — Bibliogr. s. 625-626, Abstr.
Autorzy (7)
- Szatkowski Piotr
- Stępień Adam
- AGHĆmiel Adam
- Kocorzyk Radosław
- Trąd-Wójcik Gabriela
- Gacek Ewelina
- Mastalerz Lucyna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 162732 |
|---|---|
| Data dodania do BaDAP | 2025-09-22 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.jaci.2025.04.036 |
| Rok publikacji | 2025 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Journal of Allergy and Clinical Immunology |
Abstract
Background Arachidonic acid metabolism in patients with aspirin-exacerbated respiratory disease (AERD) is characterized by an imbalance between proinflammatory and anti-inflammatory eicosanoids. In this study, we focused on end metabolites of the 15-LOX-1 and 5-LOX pathways. Objective We sought to identify possible metabolomic clusters based on plasma and urinary levels of 15-oxo-eicosatetraenoic acid (15-oxo-ETE) and 5-oxo-eicosatetraenoic acid in combination with other lipoxygenase arachidonic acid metabolites and variables. Methods Hierarchical cluster analysis was performed in 78 patients with AERD and 63 patients with aspirin-tolerant asthma (ATA), both with 23 variables. These variables included demographic, clinical, biochemical, and treatment data; sinus computed tomography findings; and plasma and urinary levels of selected eicosanoids measured by high-performance liquid chromatography and tandem mass spectrometry. Results Two clusters (endophenotypes) were distinguished in each study group. The Lund-Mackay score on paranasal sinus computed tomography and urinary leukotriene E4 levels were significantly higher, whereas urinary 15-oxo-ETE levels were significantly lower, in AERD clusters compared with ATA clusters. Patients in cluster 1AERD (vs cluster 2AERD) and cluster 1ATA (vs cluster 2ATA) were older and had higher body mass index, more severe asthma, and worse asthma control, as well as higher levels of plasma 15-hydroxyeicosatetraenoic acid, 15-oxo-ETE, and 5-hydroxyeicosatetraenoic acid. Patients with AERD had more advanced changes in the sinuses and higher urinary levels of 15-oxo-ETE and leukotriene E4 than patients with ATA. Conclusion Higher plasma and lower urinary levels of 15-oxo-ETE are associated with more severe asthma and worse asthma control in patients with AERD with older age and higher body mass index.
