Szczegóły publikacji
Opis bibliograficzny
3D printing and electrospinning of drug- and graphene-enhanced polycaprolactone scaffolds for osteochondral nasal repair / Izabella Rajzer, Anna Kurowska, Anna Nikodem, Jarosław Janusz, Adam Jabłoński, Magdalena ZIĄBKA, Elżbieta Menaszek, Jana Frankova, Wojciech PIEKARCZYK, Janusz Fabia // Materials [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1996-1944. — 2025 — vol. 18 iss. 8 art. no. 1826, s. 1–19. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 17–19, Abstr. — Publikacja dostępna online od: 2025-04-16
Autorzy (10)
- Rajzer Izabella
- Kurowska Anna
- Nikodem Anna
- Janusz Jarosław
- Jabłoński Adam
- AGHZiąbka Magdalena
- Menaszek Elżbieta
- Frankova Jana
- AGHPiekarczyk Wojciech
- Fabia Janusz
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 159479 |
|---|---|
| Data dodania do BaDAP | 2025-05-07 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ma18081826 |
| Rok publikacji | 2025 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Materials |
Abstract
A novel bi-layered scaffold, obtained via 3D printing and electrospinning, was designed to improve osteochondral region reconstruction. The upper electrospun membrane will act as a barrier against unwanted tissue infiltration, while the lower 3D-printed layer will provide a porous structure for tissue ingrowth. Graphene was integrated into the scaffold for its antibacterial properties, and the drug Osteogenon® (OST) was added to promote bone tissue regeneration. The composite scaffolds were subjected to comprehensive physical, thermal, and mechanical evaluations. Additionally, their biological functionality was assessed by means of NHAC-kn cells. The 0.5% graphene addition to PCL significantly increased strain at break, enhancing the material ductility. GNP also acted as an effective nucleating agent, raising crystallization temperatures and supporting mineralization. The high surface area of graphene facilitated rapid apatite formation by attracting calcium and phosphate ions. This was confirmed by FTIR, µCT and SEM analyses, which highlighted the positive impact of graphene on mineral deposition. The synergistic interaction between graphene nanoplatelets and Osteogenon® created a bioactive environment that enhanced cell adhesion and proliferation, and promoted superior apatite formation. These findings highlight the scaffold’s potential as a promising biomaterial for osteochondral repair and regenerative medicine.
