Szczegóły publikacji
Opis bibliograficzny
Development and characterization of novel hybrid calcium phosphate-based 3D-printed scaffolds for bone regeneration : [abstract] / Kinga KOWALSKA, Joanna P. CZECHOWSKA, Piotr PAŃTAK, Dawid KOZIEŃ, Aneta ZIMA // W: Proceedings of the Brazilian meeting on Ceramic Additive Manufacturing (CeramicAM Brasil) [Dokument elektroniczny] : [19-20/09/2024, São Carlos, São Paulo] / University of São Paulo. — Wersja do Windows. — Dane tekstowe. — São Paulo : University of São Paulo, [2024]. — e-ISBN: 978-65-272-1074-0. — S. [1-2]. — Wymagania systemowe: Adobe Reader. — Tryb dostępu: https://static.even3.com/anais/886102.pdf [2025-02-24]. — Publikacja dostępna online od: 2024-11-05
Autorzy (5)
- Kowalska Kinga
- Czechowska Joanna
- Pańtak Piotr
- Kozień Dawid
- Zima Aneta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 158315 |
|---|---|
| Data dodania do BaDAP | 2025-03-27 |
| Rok publikacji | 2024 |
| Typ publikacji | materiały konferencyjne (aut.) |
| Otwarty dostęp |  |
Abstract
Additive manufacturing techniques like robocasting are being used to create personalized, bioactive bone substitutes. Robocasting utilizes high-concentration pastes and plasticizing modifiers for optimal flow properties, producing bioceramic structures tailored to orthopedic patients. This enhances scaffold development for bone regeneration and integration with natural bone tissue. In this study novel, hybrid, bone substitutes on the basis of highly reactive alfa-tricalcium phosphate (alfa-TCP) and hydroxyapatite/methylcellulose (Au-HAp/MTC) or hydroxyapatite/chitosan (Au-HAp/CTS) modified with gold nanoparticles were obtained using robocasting. 2.5 wt.% citrus pectin in 1.0 wt.% Na2HPO4 (aq) was used as a liquid phase. Physicochemical properties of the self-setting scaffolds were tested. Phase composition of the materials was analyzed via X-ray diffraction. Two crystalline phases, hydroxyapatite and alfa-tricalcium phosphate were identified. Initial and final setting times of the biomaterials were measured. Initial setting times for both materials were within the range of 30.0 ± 1 min – 37.0 ± 2 min, and final setting times were within the range of 60.0 ± 2 min – 67.0 ± 2 min. The mechanical strength of 3D printed scaffolds was between 2.8 ± 0.6 – 3.0 ± 0.6 MPa, what makes them suitable for non-load bearing applications. In vitro bioactivity of the materials in SBF was checked and microstructure of the scaffolds was observed with SEM (Phenom Pure). SEM observations of the materials' surfaces after in vitro studies revealed high bioactive potential, indicated by the formation of apatite-like layers. The designed compositions of the pastes are suitable for 3D printing and resulting scaffolds are promising candidates for non-load-bearing clinical applications.