Szczegóły publikacji
Opis bibliograficzny
Basella alba L. (Malabar spinach) as an abundant source of betacyanins: identification, stability, and bioactivity studies on natural and processed fruit pigments / Katarzyna Sutor-Świeży, Renata Górska, Agnieszka Kumorkiewicz-Jamro, Ewa Dziedzic, Monika Bieniasz, Przemysław MIELCZAREK, Łukasz Popenda, Karol Pasternak, Małgorzata Tyszka-Czochara, Monika Baj-Krzyworzeka, Monika Stefańska, Przemysław Błyszczuk, Sławomir Wybraniec // Journal of Agricultural and Food Chemistry ; ISSN 0021-8561. — 2024 — vol. 72 iss. 6, s. 2943–2962. — Bibliogr. s. 2960–2962, Abstr. — Publikacja dostępna online od: 2024-02-01. — P. Mielczarek - dod. afiliacja: Laboratory of Proteomics and Mass Spectrometry, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
Autorzy (13)
- Sutor-Świeży Katarzyna
- Górska Renata
- Kumorkiewicz-Jamro Agnieszka
- Dziedzic Ewa
- Bieniasz Monika
- AGHMielczarek Przemysław
- Popenda Łukasz
- Pasternak Karol
- Tyszka-Czochara Małgorzata
- Baj-Krzyworzeka Monika
- Stefańska Monika
- Błyszczuk Przemysław
- Wybraniec Sławomir
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 152154 |
|---|---|
| Data dodania do BaDAP | 2024-04-09 |
| Tekst źródłowy | URL |
| DOI | 10.1021/acs.jafc.3c06225 |
| Rok publikacji | 2024 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Journal of Agricultural and Food Chemistry |
Abstract
The antioxidant and anti-inflammatory activities of acylated and decarboxylated gomphrenins, as well as Basella alba L. fruit extract, were investigated in relation to gomphrenin, known for its high biological potential. The most abundant natural acylated gomphrenins, namely, 6′-O-E-caffeoyl-gomphrenin (malabarin) and 6′-O-E-4-coumaroyl-gomphrenin (globosin), were isolated from B. alba extract for the studies. In addition, controlled thermal decarboxylation of gomphrenin in the purified B. alba extract at 65-75 °C resulted in the formation of the most prevalent decarboxylated products, including 17-decarboxy-gomphrenin and 2,17-bidecarboxy-gomphrenin, along with their isoforms. The structures of the decarboxylated pigments were confirmed by NMR analyses. Exploring the matrix effect on pigment reactivity revealed a tremendous increase in the stability of all betacyanins after the initial stage of extract purification using a cation exchanger under various conditions. This indicates the removal of a substantial portion of the unfavorable matrix from the extract, which presumably contains reactive species that could otherwise degrade the pigments. Furthermore, the high concentration of citrates played a significant role in favoring the formation of 2-decarboxy-gomphrenin to a considerable extent. In vitro screening experiments revealed that the tested compounds demonstrated strong anti-inflammatory properties in lipopolysaccharide (LPS)-activated human macrophages. This effect encompassed the selective inhibition of cytokine and chemokine release from activated macrophages, modulation of the chemotactic activity of immune cells, and the regulation of tissue remodeling mediators’ release. © 2024 The Authors. Published by American Chemical Society.
