Szczegóły publikacji
Opis bibliograficzny
In vitro and in vivo testing of stereolithography (SLA)-manufactured haemocompatible photopolymers for blood pump / Roman Major, Maciej Gawlikowski, Marcin Surmiak, Karolina Janiczak, Justyna Więcek, Przemysław Kurtyka, Martin Schwentenwein, Ewa Jasek-Gajda, Magdalena KOPERNIK, Juergen M. Lackner // Applied Sciences (Basel) [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 2076-3417. — 2024 — vol. 14 iss. 1 art. no. 383, s. 1-20. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 19-20, Abstr. — Publikacja dostępna online od: 2023-12-31
Autorzy (10)
- Major Roman
- Gawlikowski Maciej
- Surmiak Marcin
- Janiczak K.
- Więcek Justyna
- Kurtyka Przemysław
- Schwentenwein Martin
- Jasek-Gajda Ewa
- AGHKopernik Magdalena
- Lackner Juergen Markus
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 151232 |
|---|---|
| Data dodania do BaDAP | 2024-01-15 |
| Tekst źródłowy | URL |
| DOI | 10.3390/app14010383 |
| Rok publikacji | 2024 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Applied Sciences (Basel) |
Abstract
A major medical problem of state-of-the-art heart ventricular assist devices (LVADs) is device-induced thrombus formation due to inadequate blood-flow dynamics generated by the blood pump rotor. The latter is a highly complex device, with difficulties during conventional manufacturing through milling or casting. Therefore, the additive manufacturing technology relying on stereo-lithography (SLA) capable of producing parts of significantly increased freedom for a blood-flow-compatible, thrombus-risk-free design was chosen as novel and flexible technology for that type of application. However, as yet state-of-the-art SLA is not suitable to produce fully safe blood-contacting devices. Therefore, the present experiment covered chemical, mechanical, rheological, tribological, and complex biocompatibility characterization in accordance with i.a. ISO 10993 standards, including hemolysis and an acute thrombogenicity blood test on fresh animal blood (both as innovative laboratory tests to avoid animal usage in preclinical studies) with a special focus on testing demonstrators of miniaturized blood pump rotors. The conducted tests indicated acceptable biocompatibility of the material and a slight improvement in biocompatibility with surface modification. Additionally, a high biocompatibility of the tested materials was confirmed. Based on studies and simulations, stereolithography (SLA) as an additive manufacturing technology with significantly increased freedom for a blood-flow-compatible, thrombus-risk-free design was chosen as a novel and flexible technology basis in the 4DbloodROT project to enable future manufacturing of rotors with exceptional biomimetic complexity.