Szczegóły publikacji
Opis bibliograficzny
Aqueous dispersion of manganese–zinc ferrite nanoparticles protected by PEG as a $T_{2}$ MRI temperature contrast agent / Dorota LACHOWICZ, Angelika KMITA, Marta GAJEWSKA, Elżbieta TRYNKIEWICZ, Marek PRZYBYLSKI, Stephen E. Russek, Karl F. Stupic, David A. Woodrum, Krzysztof R. Gorny, Zbigniew J. Celinski, Janusz H. Hankiewicz // International Journal of Molecular Sciences [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1422-0067. — 2023 — vol. 24 iss. 22 art. no. 16458, s. 1–18. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 16–18, Abstr. — Publikacja dostępna online od: 2023-11-17. — M. Przybylski – dod. afiliacja: ACMiN AGH
Autorzy (11)
- AGHLachowicz Dorota
- AGHKmita Angelika
- AGHGajewska Marta
- AGHTrynkiewicz Elżbieta
- AGHPrzybylski Marek
- Russek Stephen E.
- Stupic Karl
- Woodrum David A.
- Górny Krzysztof R.
- Celiński Zbigniew J.
- Hankiewicz Janusz H.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 150222 |
|---|---|
| Data dodania do BaDAP | 2023-12-15 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ijms242216458 |
| Rok publikacji | 2023 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Molecular Sciences |
Abstract
Mixed manganese–zinc ferrite nanoparticles coated with PEG were studied for their potential usefulness in MRI thermometry as temperature-sensitive contrast agents. Particles in the form of an 8.5 nm core coated with a 3.5 nm layer of PEG were fabricated using a newly developed, one-step method. The composition of Mn0.48Zn0.46Fe2.06O4 was found to have a strong thermal dependence of magnetization in the temperature range between 5 and 50 °C. Nanoparticles suspended in an agar gel mimicking animal tissue and showing non-significant impact on cell viability in the biological test were studied with NMR and MRI over the same temperature range. For the concentration of 0.017 mg/mL of Fe, the spin–spin relaxation time T2 increased from 3.1 to 8.3 ms, while longitudinal relaxation time T1 shows a moderate decrease from 149.0 to 125.1 ms. A temperature map of the phantom exposed to the radial temperature gradient obtained by heating it with an 808 nm laser was calculated from T2 weighted spin-echo differential MR images. Analysis of temperature maps yields thermal/spatial resolution of 3.2 °C at the distance of 2.9 mm. The experimental relaxation rate R2 data of water protons were compared with those obtained from calculations using a theoretical model incorporating the motion averaging regime.