Szczegóły publikacji
Opis bibliograficzny
Non-eosinophilic asthma in nonsteroidal anti-inflammatory drug exacerbated respiratory disease / Lucyna Mastalerz, Natalia Celejewska-Wójcik, Adam ĆMIEL, Krzysztof Wójcik, Joanna Szaleniec, Karolina Hydzik-Sobocińska, Jerzy Tomik, Marek Sanak // Clinical and Translational Allergy [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 2045-7022. — 2023 — vol. 13 iss. 3 art. no. e12235, s. 1–9. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 8–9, Abstr. — Publikacja dostępna online od: 2023-03-13
Autorzy (8)
- Mastalerz Lucyna
- Celejewska-Wójcik Natalia
- AGHĆmiel Adam
- Wójcik Krzysztof t
- Szaleniec Joanna
- Hydzik-Sobocińska Karolina
- Tomik Jerzy
- Sanak Marek
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 150049 |
|---|---|
| Data dodania do BaDAP | 2023-12-05 |
| Tekst źródłowy | URL |
| DOI | 10.1002/clt2.12235 |
| Rok publikacji | 2023 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Clinical and Translational Allergy |
Abstract
Background: The cellular inflammatory pattern of nonsteroidal anti-inflammatory drug–exacerbated respiratory disease (N-ERD) is heterogeneous. However, data on the heterogeneity of non-eosinophilic asthma (NEA) with aspirin hypersensitivity are scanty. By examination of N-ERD patients based on clinical data and eicosanoid biomarkers we aimed to identify NEA endotypes potentially guiding clinical management. Methods: Induced sputum was collected from patients with N-ERD. Sixty six patients (49.6% of 133 N-ERD) with NEA were included in the hierarchical cluster analysis based on clinical and laboratory data. The quality of clustering was evaluated using internal cluster validation with different indices and a practical decision tree was proposed to simplify stratification of patients. Results: The most frequent NEA pattern was paucigranulocytic (PGA; 75.8%), remaining was neutrophilic asthma (NA; 24.2%). Four clusters were identified. Cluster #3 included the highest number of NEA patients (37.9%) with severe asthma and PGA pattern (96.0%). Cluster #1 (24.2%) included severe only asthma, with a higher prevalence of NA (50%). Cluster #2 (25.8%) comprised well-controlled mild or severe asthma (PGA; 76.5%). Cluster #4 contained only 12.1% patients with well-controlled moderate asthma (PGA; 62.5%). Sputum prostaglandin D2 levels distinguished cluster #1 from the remaining clusters with an area under the curve of 0.94. Conclusions: Among identified four NEA subtypes, clusters #3 and #1 represented N-ERD patients with severe asthma but a different inflammatory signatures. All the clusters were discriminated by sputum PGD2 levels, asthma severity, and age of patients. The heterogeneity of non-eosinophilic N-ERD suggests a need for novel targeted interventions. © 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
