Szczegóły publikacji
Opis bibliograficzny
Synthesis and characterization of antibacterial chitosan films with ciprofloxacin in acidic conditions / Dominik Sikorski, Piotr Rosiak, Łukasz Janczewski, Marek J. Potrzebowski, Dorota Kregiel, Sławomir Kaźmierski, Damian Neubauer, Beata Kolesińska, Justyna Frączyk, Anna ADAMCZYK, Zbigniew Draczyński // International Journal of Molecular Sciences [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1422-0067. — 2023 — vol. 24 iss. 20 art. no. 15163, s. 1–18. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 16–18, Abstr. — Publikacja dostępna online od: 2023-10-13
Autorzy (11)
- Sikorski Dominik
- Rosiak Piotr
- Janczewski Łukasz
- Potrzebowski Marek J.
- Kregiel Dorota
- Kaźmierski Sławomir
- Neubauer Damian
- Kolesińska Beata
- Frączyk Justyna
- AGHAdamczyk Anna
- Draczyński Zbigniew
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 149604 |
|---|---|
| Data dodania do BaDAP | 2023-10-25 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ijms242015163 |
| Rok publikacji | 2023 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Molecular Sciences |
Abstract
This work presents the results of research on obtaining chitosan (CS) films containing on their surface ciprofloxacin (CIP). A unique structure was obtained that not only gives new properties to the films, but also changes the way of coverage and structure of the surface. The spectroscopic test showed that in the process of application of CIP on the surface of CS film, CIP was converted from its crystalline form to an amorphic one, hence improving its bioavailability. This improved its scope of microbiological effect. The research was carried out on the reduction of CIP concentration during the process of CIP adhesion to the surface of chitosan films. The antibacterial activity of the CS films with and without the drug was evaluated in relation to Escherichia coli and Staphylococcus aureus, as well as Candida albicans and Penicillium expansum. Changes in the morphology and roughness of membrane surfaces after the antibacterial molecule adhesion process were tested with atomic force microscopy (AFM) and scanning electron microscopy (SEM). Structural analysis of CS and its modifications were confirmed with Fourier-transform spectroscopy in the infrared by an attenuated total reflectance of IR radiation (FTIR-ATR) and solid-state nuclear magnetic resonance (NMR).