Szczegóły publikacji

Opis bibliograficzny

Autorzy (9)

• AGHBenko Aleksandra
• Medina-Cruz David
• AGHWilk Sebastian
• AGHZiąbka Magdalena
• AGHZagrajczuk Barbara
• Menaszek Elżbieta
• Barczyk-Woźnicka Olga
• Guisbiers Gregory
• Webster Thomas Jay

Dane bibliometryczne

ID BaDAP	149094
Data dodania do BaDAP	2023-10-02
Tekst źródłowy	URL
DOI	10.1039/D3NR02923A
Rok publikacji	2023
Typ publikacji	artykuł w czasopiśmie
Otwarty dostęp
Czasopismo/seria	Nanoscale

Abstract

Due to their high strength, low weight, and biologically-inspired dimensions, carbon nanotubes have found wide interest across all of medicine. In this study, four types of highly dispersible multi-walled carbon nanotubes (MWCNTs) of similar dimensions, but slightly different chemical compositions, were tested and compared with an unmodified material to verify the impact their surface chemistry has on the cytocompatibility, anticancer, inflammation, and antibacterial properties. Minute changes in the chemical composition weare found to greatly affect the biological performance of the MWCNTs. Specifically, The the CNTs with presence of a high sharelarge number of carbon atoms with a +2 coordination number induced cytotoxicity in macrophages and melanoma cells, and had a moderate antibacterial effect against Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria strains, all while being cytocompatible towards human dermal fibroblasts. Moreover, Substituting substituting some of the OH groups with ammonia diminisheds their cytotoxicity towards macrophages while still maintaining the rest of theaforementioned positive qualities. At the same time, CNTs with a large number high share of carbon atoms with a +3 coordination number yielded materials withhad a high innate cytocompatibility towards normal healthy cells but were, cytotoxicity towards cancer cells , and bacteria. The latter was high antibacterial properties which were further boosted by reacting the MWCNT the CNTs’ carboxyl groups with ammonia. Although requiring more studiesfurther analyses, The the results of this study, thus, paved the way forintroduce new MWCNTs that without drugs can treat cancer, inflammation, and/or infection while still remaining cytocompatible with mammalian cells. aware planning of a new class of drug delivery vehicles, photothermal materials, or as photodynamic therapy agents, with innate antibacterial and anticancer properties.

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