Szczegóły publikacji
Opis bibliograficzny
3D-printed polycaprolactone implants modified with bioglass and Zn-doped bioglass / Izabella Rajzer, Anna Kurowska, Jana Frankova, Renáta Sklenářová, Anna Nikodem, Michał DZIADEK, Adam Jabłoński, Jarosław Janusz, Piotr Szczygieł, Magdalena ZIĄBKA // Materials [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1996-1944. — 2023 — vol. 16 iss. 3 art. no. 1061, s. 1-16. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 14-16, Abstr. — Publikacja dostępna online od: 2023-01-25. — M. Dziadek – dod. afiliacja: Faculty of Chemistry, Jagiellonian University
Autorzy (10)
Rajzer IzabellaKurowska AnnaFrankova JanaSklenářová RenátaNikodem AnnaAGHDziadek MichałJabłoński AdamJanusz JarosławSzczygieł PiotrAGHZiąbka MagdalenaSłowa kluczowe
Dane bibliometryczne
| ID BaDAP | 144996 |
|---|---|
| Tekst źródłowy | URL |
| DOI | 10.3390/ma16031061 |
| Rok publikacji | 2023 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Materials |
Abstract
In this work, composite filaments in the form of sticks and 3D-printed scaffolds were investigated as a future component of an osteochondral implant. The first part of the work focused on the development of a filament modified with bioglass (BG) and Zn-doped BG obtained by injection molding. The main outcome was the manufacture of bioactive, strong, and flexible filament sticks of the required length, diameter, and properties. Then, sticks were used for scaffold production. We investigated the effect of bioglass addition on the samples mechanical and biological properties. The samples were analyzed by scanning electron microscopy, optical microscopy, infrared spectroscopy, and microtomography. The effect of bioglass addition on changes in the SBF mineralization process and cell morphology was evaluated. The presence of a spatial microstructure within the scaffolds affects their mechanical properties by reducing them. The tensile strength of the scaffolds compared to filaments was lower by 58–61%. In vitro mineralization experiments showed that apatite formed on scaffolds modified with BG after 7 days of immersion in SBF. Scaffold with Zn-doped BG showed a retarded apatite formation. Innovative 3D-printing filaments containing bioglasses have been successfully applied to print bioactive scaffolds with the surface suitable for cell attachment and proliferation.