Szczegóły publikacji
Opis bibliograficzny
Insight in superiority of the hydrophobized gentamycin in terms of antibiotics delivery to bone tissue / Konrad KWIECIEŃ, Iwona PUDEŁKO, Karolina KNAP, Katarzyna RECZYŃSKA-KOLMAN, Małgorzata KROK-BORKOWICZ, Dorota Ochońska, Monika Brzychczy-Włoch, Elżbieta PAMUŁA // International Journal of Molecular Sciences [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1422-0067. — 2022 — vol. 23 iss. 20 art. no. 12077, s. 1–19. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 17–19, Abstr. — Publikacja dostępna online od: 2022-10-11
Autorzy (8)
- AGHKwiecień Konrad
- AGHPudełko-Prażuch Iwona
- AGHKnap-Matlęga Karolina
- AGHReczyńska-Kolman Katarzyna
- AGHKrok-Borkowicz Małgorzata
- Ochońska Dorota
- Brzychczy-Włoch Monika
- AGHPamuła Elżbieta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 143126 |
|---|---|
| Data dodania do BaDAP | 2022-11-02 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ijms232012077 |
| Rok publikacji | 2022 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Molecular Sciences |
Abstract
Bone infections are a serious problem to cure, as systemic administration of antibiotics is not very effective due to poor bone vascularization. Therefore, many drug delivery systems are investigated to solve this problem. One of the potential solutions is the delivery of antibiotics from poly(L-actide-co-glycolide) (PLGA) nanoparticles suspended in the gellan gum injectable hydrogel. However, the loading capacity and release kinetics of the system based on hydrophilic drugs (e.g., gentamycin) and hydrophobic polymers (e.g., PLGA) may not always be satisfying. To solve this problem, we decided to use hydrophobized gentamycin obtained by ion-pairing with dioctyl sulfosuccinate sodium salt (AOT). Herein, we present a comparison of the PLGA nanoparticles loaded with hydrophobic or hydrophilic gentamycin and suspended in the hydrogel in terms of physicochemical properties, drug loading capacity, release profiles, cytocompatibility, and antibacterial properties. The results showed that hydrophobic gentamycin may be combined in different formulations with the hydrophilic one and is superior in terms of encapsulation efficiency, drug loading, release, and antibacterial efficacy with no negative effect on the NPs morphology or hydrogel features. However, the cytocompatibility of hydrophobic gentamycin might be lower, consequently more extensive study on its biological properties should be provided to evaluate a safe dose.
