Szczegóły publikacji
Opis bibliograficzny
New voltammetry sensor for antipsychotic drug – mirtazapine based on glassy carbon electrode cover with carbon black nanoparticles / Martyna ŁAWRYWIANIEC, Joanna SMAJDOR, Beata PACZOSA-BATOR, Robert PIECH // Acta Poloniae Pharmaceutica Drug Research ; ISSN 0001-6837. — 2022 — vol. 79 no. 3, s. 333–341. — Bibliogr. s. 340–341, Abstr.
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Dane bibliometryczne
| ID BaDAP | 141944 |
|---|---|
| Data dodania do BaDAP | 2022-10-04 |
| Tekst źródłowy | URL |
| DOI | 10.32383/appdr/150540 |
| Rok publikacji | 2022 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Acta Poloniae Pharmaceutica Drug Research |
Abstract
A novel, simple, and highly sensitive voltammetry method for antidepressant drug - mirtazapine - determination was successfully developed. The proposed sensor is based on a modification layer consisting of carbon black nanoparticles (CB), applied on the glassy carbon electrode surface. This paper presents the possibilities of carbon black as a substitute for other carbon materials commonly used in electrochemistry. Under optimal conditions, a linear voltammetric dependence of mirtazapine was obtained for its concentration from 0.5 to 3.5·10 -6 mol/L with a detection limit of 38·10 -9 mol/L for a deposition time of 60 s. Using the cyclic voltammetry technique, the MRT oxidation process was defined as a diffusion-controlled, irreversible reaction with one electron and one proton exchange. The reproducibility of the method was defined as the relative standard deviation value (RSD%) and was equal to 3.15% for 10 repetitions. Furthermore, the proposed method was successfully applied for the determination of mirtazapine in pharmaceutical products and synthetic human urine samples; the recovery obtained was in the range of 94.4 to 104.9%.
