Szczegóły publikacji
Opis bibliograficzny
Altered elemental distribution in male rat brain tissue as a predictor of Glioblastoma Multiforme Growth — studies using SR-XRF microscopy / Karolina PŁANETA, Zuzanna Setkowicz, Mateusz Czyżycki, Natalia JANIK-OLCHAWA, Damian Ryszawy, Krzysztof Janeczko, Rolf Simon, Tilo Baumbach, Joanna CHWIEJ // International Journal of Molecular Sciences [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1422-0067. — 2022 — vol. 23 iss. 2 art. no. 703, s. 1–20. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 17–20, Abstr. — Publikacja dostępna online od: 2022-01-09. — M. Czyżycki – afiliacja: Laboratory for Applications of Synchrotron Radiation, Karlsruhe Institute of Technology, Germany
Autorzy (9)
- AGHOlbrich Karolina L.
- Setkowicz Zuzanna
- Czyżycki Mateusz
- AGHJanik-Olchawa Natalia
- Ryszawy Damian
- Janeczko Krzysztof
- Simon Rolf
- Baumbach Tilo
- AGHChwiej Joanna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 138635 |
|---|---|
| Data dodania do BaDAP | 2022-01-21 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ijms23020703 |
| Rok publikacji | 2022 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Molecular Sciences |
Abstract
Glioblastoma multiforme (GBM) is a particularly malignant primary brain tumor. Despite enormous advances in the surgical treatment of cancer, radio- and chemotherapy, the average survival of patients suffering from this cancer does not usually exceed several months. For obvious ethical reasons, the search and testing of the new drugs and therapies of GBM cannot be carried out on humans, and for this purpose, animal models of the disease are most often used. However, to assess the efficacy and safety of the therapy basing on these models, a deep knowledge of the pathological changes associated with tumor development in the animal brain is necessary. Therefore, as part of our study, the synchrotron radiation-based X-ray fluorescence microscopy was applied for multi-elemental micro-imaging of the rat brain in which glioblastoma develops. Elemental changes occurring in animals after the implantation of two human glioma cell lines as well as the cells taken directly from a patient suffering from GBM were compared. Both the extent and intensity of elemental changes strongly correlated with the regions of glioma growth. The obtained results showed that the observation of elemental anomalies accompanying tumor development within an animal’s brain might facilitate our understanding of the pathogenesis and progress of GBM and also determine potential biomarkers of its extension. The tumors appearing in a rat’s brain were characterized by an increased accumulation of Fe and Se, whilst the tissue directly surrounding the tumor presented a higher accumulation of Cu. Furthermore, the results of the study allow us to consider Se as a potential elemental marker of GBM progression.
