Szczegóły publikacji
Opis bibliograficzny
Addressing the osteoporosis problem - multifunctional injectable hybrid materials for controlling local bone tissue remodeling / Adriana GILARSKA, Alicja Hizn, Monika Bzowska, Grzegorz Dyduch, Kamil Kamiński, Maria Nowakowska, Joanna Lewandowska-Łańcucka // ACS Applied Materials & Interfaces ; ISSN 1944-8244. — 2021 — vol. 13 iss. 42, s. 49762–49779. — Bibliogr. s. 49777–49779, Abstr. — Publikacja dostępna online od: 2021-10-13. — A. Gilarska - pierwsza afiliacja: Faculty of Chemistry, Jagiellonian University
Autorzy (7)
- AGHGilarska Adriana
- Hinz Alicja
- Bzowska Monika
- Dyduch Grzegorz
- Kamiński Kamil
- Nowakowska Maria
- Lewandowska-Łańcucka Joanna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 137561 |
|---|---|
| Data dodania do BaDAP | 2021-11-16 |
| Tekst źródłowy | URL |
| DOI | 10.1021/acsami.1c17472 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | ACS Applied Materials & Interfaces |
Abstract
Novel multifunctional biomimetic injectable hybrid systems were synthesized. The physicochemical as well as biological in vitro and in vivo tests demonstrated that they are promising candidates for bone tissue regeneration. The hybrids are composed of a biopolymeric collagen/chitosan/hyaluronic acid matrix and amine group-functionalized silica particles decorated with apatite to which the alendronate molecules were coordinated. The components of these systems were integrated and stabilized by cross-linking with genipin, a compound of natural origin. They can be precisely injected into the diseased tissue in the form of a viscous sol or a partially cross-linked hydrogel, where they can serve as scaffolds for locally controlled bone tissue regeneration/remodeling by supporting the osteoblast formation/proliferation and maintaining the optimal osteoclast level. These materials lack systemic toxicity. They can be particularly useful for the repair of small osteoporotic bone defects.
