Szczegóły publikacji
Opis bibliograficzny
Patients with alcohol use disorder increase pain and analgesics use: a nationwide population-based cohort study / Hao-Yuan Hung, Wu-Chien Chien, Chi-Hsiang Chung, Li-Ting Kao, Lok-Hi Chow, Yuan-Hao Chen, Jolanta H. Kotlińska, Jerzy SILBERRING, Eagle Yi-Kung Huang // Drug and Alcohol Dependence ; ISSN 0376-8716. — 2021 — vol. 229 pt. A art. no. 109102, s. 1–10. — Bibliogr. s. 9–10, Abstr. — Publikacja dostępna online od: 2021-09-24
Autorzy (9)
- Hung Hao-Yuan
- Chien Wu-Chien
- Chung Chi-Hsiang
- Kao Li-Ting
- Chow Lok-Hi
- Chen Yuan-Hao
- Kotlińska Jolanta Helena
- AGHSilberring Jerzy
- Huang Eagle Yi-Kung
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 137333 |
|---|---|
| Data dodania do BaDAP | 2021-10-29 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.drugalcdep.2021.109102 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Drug and Alcohol Dependence |
Abstract
Background: Alcohol has dual effects on many systems, including the pain system. We will test whether and how chronic alcohol consumption enhances pain sensation to develop pain disorder. Methods: We conducted a retrospective matched cohort study using data from the National Health Insurance Research Database (NHIRD) in Taiwan, in patients with and without alcohol use disorder (AUD). This study enrolled 19,174 individuals with AUD as study cohort and 19,174 propensity score-matched individuals without AUD as comparison cohort. The outcome was the incidence of pain disorders and the need for analgesics. The hazard ratios of pain disorders and the need for analgesics were evaluated using Cox proportional hazard regression analysis after adjusting for age, sex, index year, comorbidities, urbanization, areas of residence, and insurance premium. Results: The 14 years of follow-up showed that AUD patients had a higher adjusted hazard ratio (aHR) for developing pain disorders than in non-AUD controls [aHR= 1.290, 95% confidence interval (CI): 1.045–1.591]. Besides, AUD patients had a higher risk of analgesic use (aHR = 1.081, 95% CI: 1.064–1.312), including opioids and non-opioid analgesics. Most importantly, AUD patients required more days of analgesic use, increased dose of analgesics, and higher costs of analgesics. Moreover, AUD patients had more anemia (aHR=2.772, 95% CI: 2.581–2.872), which could be a mediating factor. Conclusions: AUD patients had higher risks of developing pain disorders and subsequently increased analgesic demand. These results suggest that AUD worsened pain, and pain syndrome is correlated with the duration of chronic alcohol exposure. © 2021 Elsevier B.V.
