Szczegóły publikacji
Opis bibliograficzny
In search of effective UiO-66 metal-organic frameworks for artificial kidney application / Klaudia Dymek, Grzegorz Kurowski, Łukasz Kuterasiński, Roman Jędrzejczyk, Magdalena SZUMERA, Maciej SITARZ, Anna Pajdak, Łukasz Kurach, Anna Boguszewska-Czubara, Przemysław J. Jodłowski // ACS Applied Materials & Interfaces ; ISSN 1944-8244. — 2021 — vol. 13 iss. 38, s. 45149–45160. — Bibliogr. s. 45159–45160, Abstr. — Publikacja dostępna online od: 2021-09-14
Autorzy (10)
- Dymek Klaudia
- Kurowski Grzegorz
- Kuterasiński Łukasz
- Jędrzejczyk Roman J.
- AGHSzumera Magdalena
- AGHSitarz Maciej
- Pajdak Anna
- Kurach Łukasz
- Boguszewska-Czubara Anna
- Jodłowski Przemysław J.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 136657 |
|---|---|
| Data dodania do BaDAP | 2021-10-01 |
| Tekst źródłowy | URL |
| DOI | 10.1021/acsami.1c05972 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | ACS Applied Materials & Interfaces |
Abstract
The removal of uremic toxins from patients with acute kidney injury is a key issue in improving the quality of life for people requiring peritoneal dialysis. The currently utilized method for the removal of uremic toxins from the human organism is hemodialysis, performed on semipermeable membranes where the uremic toxins, along with small molecules, are separated from proteins and blood cells. In this study, we describe a mixed-linker modulated synthesis of zirconium-based metal–organic frameworks for efficient removal of uremic toxins. We determined that the efficient adsorption of uremic toxins is achieved by optimizing the ratio between −amino functionalization of the UiO-66 structure with 75% of −NH2 groups within organic linker structure. The maximum adsorption of hippuric acid and 3-indoloacetic acid was achieved by UiO-66-NH2 (75%) and by UiO-66-NH2 (75%) 12.5% HCl prepared by modulated synthesis. Furthermore, UiO-66-NH2 (75%) almost completely adsorbs 3-indoloacetic acid bound to bovine serum albumin, which was used as a model protein to which uremic toxins bind in the human body. The high adsorption capacity was confirmed in recyclability test, which showed almost 80% removal of 3-indoloacetic acid after the third adsorption cycle. Furthermore, in vitro cytotoxicity tests as well as hemolytic activity assay have proven that the UiO-66-based materials can be considered as potentially safe for hemodialytic purposes in living organisms.