Szczegóły publikacji
Opis bibliograficzny
Boron-rich boron carbide nanoparticles as a carrier in boron neutron capture therapy: their influence on tumor and immune phagocytic cells / Dawid KOZIEŃ, Bożena Szermer-Olearnik, Andrzej Rapak, Agnieszka Szczygieł, Natalia Anger-Góra, Janusz Boratyński, Elżbieta Pajtasz-Piasecka, Mirosław M. BUĆKO, Zbigniew PĘDZICH // Materials [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1996-1944. — 2021 — vol. 14 iss. 11 art. no. 3010, s. 1–13. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 12–13, Abstr. — Publikacja dostępna online od: 2021-06-02
Autorzy (9)
- AGHKozień Dawid
- Szermer-Olearnik Bożena
- Rapak Andrzej
- Szczygieł Agnieszka
- Anger-Góra Natalia
- Boratyński Janusz
- Pajtasz-Piasecka Elżbieta
- AGHBućko Mirosław
- AGHPędzich Zbigniew
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 134431 |
|---|---|
| Data dodania do BaDAP | 2021-06-02 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ma14113010 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Materials |
Abstract
The aim of the work was to study the interaction between boron-rich boron carbide nanoparticles and selected tumor and immune phagocytic cells. Experiments were performed to investigate the feasibility of the application of boron carbide nanoparticles as a boron carrier in boron neutron capture therapy. Boron carbide powder was prepared by the direct reaction between boron and soot using the transport of reagents through the gas phase. The powder was ground, and a population of nanoparticles with an average particle size about 80 nm was selected by centrifugation. The aqueous suspension of the nanoparticles was functionalized with human immunoglobulins or FITC-labeled human immunoglobulins and was then added to the MC38 murine colon carcinoma and to the RAW 264.7 cell line of mouse macrophages. Flow cytometry analysis was used to determine interactions between the functionalized boron carbide nanoparticles and respective cells. It was shown that B4C–IgG nanoconjugates may bind to phagocytic cells to be internalized by them, at least partially, whereas such nanoconjugates can only slightly interact with molecules on the cancer cells’ surface.
