Szczegóły publikacji
Opis bibliograficzny
An insight into the stages of ion leakage during red blood cell storage / Anna Zimna, Magdalena Kaczmarska, Ewa Szczęsny-Małysiak, Aleksandra WAJDA, Katarzyna Bułat, Fatih Celal Alcicek, Małgorzata Zygmunt, Tomasz Sacha, Katarzyna Maria Marzec // International Journal of Molecular Sciences [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 1422-0067. — 2021 — vol. 22 iss. 6 art. no. 2885, s. 1–16. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 13–16, Abstr. — Publikacja dostępna online od: 2021-03-12. — A. Wajda – dod. afiliacja: Jagiellonian Centre for Experimental Therapeutics, Jagiellonian University; K. Bułat, K. Marzec – afiliacja: Jagiellonian Centre for Experimental Therapeutics, Jagiellonian University
Autorzy (9)
- Zimna Anna
- Kaczmarska Magdalena
- Szczęsny-Małysiak Ewa
- AGHWajda Aleksandra Anna
- Bułat Katarzyna
- Alcicek Fatih Celal
- Zygmunt Małgorzata
- Sacha Tomasz
- Marzec Katarzyna M.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 133116 |
|---|---|
| Data dodania do BaDAP | 2021-03-16 |
| Tekst źródłowy | URL |
| DOI | 10.3390/ijms22062885 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | International Journal of Molecular Sciences |
Abstract
Packed red blood cells (pRBCs), the most commonly transfused blood product, are exposed to environmental disruptions during storage in blood banks. In this study, temporal sequence of changes in the ion exchange in pRBCs. Standard techniques commonly used in electrolyte measurements were implemented. The relationship between ion exchange and red blood cells (RBCs) morphology was assessed with use of atomic force microscopy with reference to morphological parameters. Variations observed in the Na+, K+, Cl−, H+, HCO3−, and lactate ions concentration show a complete picture of singly-charged ion changes in pRBCs during storage. Correlation between the rate of ion changes and blood group type, regarding the limitations of our research, suggested, that group 0 is the most sensitive to the time-dependent ionic changes. Additionally, the impact of irreversible changes in ion exchange on the RBCs membrane was observed in nanoscale. Results demonstrate that the level of ion leakage that leads to destructive alterations in biochemical and morphological properties of pRBCs depend on the storage timepoint.
