Szczegóły publikacji
Opis bibliograficzny
Effects of process parameters on structure and properties of melt-blown poly(lactic acid) nonwovens for skin regeneration / Ewa DZIERZKOWSKA, Anna Ścisłowska-Czarnecka, Marcin Kudzin, Maciej Boguń, Piotr SZATKOWSKI, Marcin GAJEK, Kamil KORNAUS, Magdalena Chadzińska, Ewa STODOLAK-ZYCH // Journal of Functional Biomaterials [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 2079-4983. — 2021 — vol. 12 iss. 1 art. no. 16, s. 1–17. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 15–17, Abstr. — Publikacja dostępna online od: 2021-02-26
Autorzy (9)
- AGHKaniuk Ewa Zofia
- Ścisłowska-Czarnecka Anna
- Kudzin Marcin
- Boguń Maciej
- AGHSzatkowski Piotr
- AGHGajek Marcin
- AGHKornaus Kamil
- Chadzińska Magdalena
- AGHStodolak-Zych Ewa
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 132814 |
|---|---|
| Data dodania do BaDAP | 2021-03-03 |
| Tekst źródłowy | URL |
| DOI | 10.3390/jfb12010016 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Journal of Functional Biomaterials |
Abstract
Skin regeneration requires a three-dimensional (3D) scaffold for cell adhesion, growth and proliferation. A type of the scaffold offering a 3D structure is a nonwoven material produced via a melt-blown technique. Process parameters of this technique can be adapted to improve the cellular response. Polylactic acid (PLA) was used to produce a nonwoven scaffold by a melt-blown technique. The key process parameters, i.e., the head and air temperature, were changed in the range from 180–270 °C to obtain eight different materials (MB1–MB8). The relationships between the process parameters, morphology, porosity, thermal properties and the cellular response were explored in this study. The mean fiber diameters ranged from 3 to 120 µm. The average material roughness values were between 47 and 160 µm, whereas the pore diameters ranged from 5 to 400 µm. The calorimetry thermograms revealed a correlation between the temperature parameters and crystallization. The response of keratinocytes and macrophages exhibited a higher cell viability on thicker fibers. The cell-scaffold interaction was observed via SEM after 7 days. This result proved that the features of melt-blown nonwoven scaffolds depended on the processing parameters, such as head temperature and air temperature. Thanks to examinations, the most suitable scaffolds for skin tissue regeneration were selected.
