Szczegóły publikacji
Opis bibliograficzny
In vitro haemocompatibility assessment of acrylic acid deposited on solid, polyurethane substrate / Roman Major, Magdalena KOPERNIK, Aleksandra Kuźmińska, Gabriela Imbir, Hanna Plutecka, Małgorzata Pomorska, Tomasz Ciach, Juergen Markus Lackner // Colloids and Surfaces. B, Biointerfaces ; ISSN 0927-7765. — 2021 — vol. 199 art. no. 111562, s. 1-9. — Bibliogr. s. 8-9, Abstr. — Publikacja dostępna online od: 2021-01-06
Autorzy (8)
- Major Roman W.
- AGHKopernik Magdalena
- Kuźmińska Aleksandra
- Imbir-Szewczyk Gabriela
- Plutecka Hanna
- Pomorska Małgorzata
- Ciach Tomasz
- Lackner Juergen Markus
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 132049 |
|---|---|
| Data dodania do BaDAP | 2021-01-14 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.colsurfb.2021.111562 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Colloids and Surfaces, B, Biointerfaces |
Abstract
The main purpose of the work was to assess the haemocompatible properties of polyurethane discs with a modified surface dedicated to cardiovascular system regeneration. They were coated with acrylic acid-based material to inhibit the activation of the blood coagulation cascade. This coating improved the wettability of the material, leading to the prevention of protein adsorption on the surface. The blood-material interaction was analyzed in dynamic conditions with a specially designed tester, which helps to control blood-material interaction under high shear stress conditions. The corresponding numerical model of the tester was also developed by finite volume method (FVM). The 3D FVM model allows the determination of shear stresses applying different flow and boundary conditions representing blood-material interactions. The haemocompatibility analyses were performed through in vitro tests using a blood flow simulator. They revealed a low probability of activation of blood coagulation and low leukocyte activation. The original mechanical set-up to test the blood-material interaction helped to prove that acrylic acid-based coatings expressed good haemocompatible properties.
