Szczegóły publikacji
Opis bibliograficzny
Functionalized tricalcium phosphate and poly(3-hydroxyoctanoate) derived composite scaffolds as platforms for the controlled release of diclofenac / Szymon SKIBIŃSKI, Ewelina CICHOŃ, Katarzyna Haraźna, Elena Marcello, Ipsita Roy, Małgorzata Witko, Anna ŚLÓSARCZYK, Joanna CZECHOWSKA, Maciej Guzik, Aneta ZIMA // Ceramics International ; ISSN 0272-8842. — Tytuł poprz.: Ceramurgia International ; ISSN: 0390-5519. — 2021 — vol. 47 iss. 3, s. 3876–3883. — Bibliogr. s. 3882–3883, Abstr. — Publikacja dostępna online od: 2020-09-28
Autorzy (10)
- AGHSkibiński Szymon
- AGHCichoń Ewelina
- Haraźna Katarzyna
- Marcello Elena
- Roy Ipsita
- Witko Małgorzata
- AGHŚlósarczyk Anna
- AGHCzechowska Joanna
- Guzik Maciej
- AGHZima Aneta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 131752 |
|---|---|
| Data dodania do BaDAP | 2021-01-12 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.ceramint.2020.09.248 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Ceramics International |
Abstract
Novel bone substitutes such as highly porous ceramic scaffolds can serve as platforms for delivering active molecules. A common problem is to control the release of the drug, therefore, it is beneficial to use a drug-functionalized polymer coating. In this study, β-tricalcium phosphate-based porous scaffolds were obtained and coated with diclofenac-functionalized biopolymer – poly(3-hydroxyoctanoate) – P(3HO). To the best of our knowledge, studies using P(3HO) as a component in ceramic-polymer based drug delivery system for bone tissue regeneration have not yet been reported. Presented materials were comprehensively investigated by various techniques such as powder X-ray diffraction, scanning electron microscopy with energy dispersive spectroscopy, hydrostatic weighing and compression tests, pH and ionic conductivity measurements, high-performance liquid chromatography and in vitro cytotoxicity studies. The obtained diclofenac-loaded composite was not only characterised by controlled and sustained drug release, but also possessed improved mechanical properties. Moreover, the precipitation of apatite-like forms on its surface was observed after incubation in simulated body fluid, which indicates its bioactive potential. After 24 hours no cytotoxic effect on MC3T3-E1 mouse preosteoblastic cells was confirmed using indirect cytotoxicity studies. Thus, this promising multifunctional composite scaffold can be a promising candidate as an anti-inflammatory drug-delivery system in bone tissue engineering.
