Szczegóły publikacji
Opis bibliograficzny
PCL and PCL/bioactive glass biomaterials as carriers for biologically active polyphenolic compounds: comprehensive physicochemical and biological evaluation / Michał DZIADEK, Kinga Dziadek, Kamila CHĘCIŃSKA, Barbara ZAGRAJCZUK, Monika Golda-Cepa, Monika Brzychczy-Wloch, Elzbieta Menaszek, Aneta Kopec, Katarzyna CHOLEWA-KOWALSKA // Bioactive Materials [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 2452-199X. — 2021 — vol. 6 iss. 6, s. 1811–1826. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 1824–1826, Abstr. — Publikacja dostępna online od: 2020-12-05. — M. Dziadek - pierwsza afiliacja: Jagiellonian University
Autorzy (9)
- AGHDziadek Michał
- Dziadek Kinga
- AGHChęcińska Kamila
- AGHZagrajczuk Barbara
- Golda-Cepa Monika
- Brzychczy-Włoch Monika
- Menaszek Elżbieta
- Kopec Aneta
- AGHCholewa-Kowalska Katarzyna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 131648 |
|---|---|
| Data dodania do BaDAP | 2020-12-17 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.bioactmat.2020.11.025 |
| Rok publikacji | 2021 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Bioactive Materials |
Abstract
In this work, polymeric and bioactive glass (BG)-modified composite films were successfully loaded with polyphenols (PPh) extracted from sage. It was hypothesized that PPh, alone and in combination with BGs particles, would affect physicochemical and biological properties of the films. Furthermore, sol-gel-derived BG particles would serve as an agent for control the release of the polyphenolic compounds, and other important properties related to the presence of PPh. The results showed that polyphenolic compounds significantly modified numerous material properties and also acted as biologically active substances. On the one hand, PPh can be considered as plasticizers for PCL, on the other hand, they can act as coupling agent in composite materials, improving their mechanical performance. The presence of PPh in materials improved their hydrophilicity and apatite-forming ability, and also provided antioxidant activity. What is important is that the aforementioned properties and kinetics of PPh release can be modulated by the use of various concentrations of PPh, and by the modification of PCL matrix with sol-gel-derived BG particles, capable of binding PPh. The films containing the lowest concentration of PPh exhibited cytocompatibility, significantly increased alkaline phosphatase activity and the expression of bone extracellular matrix proteins (osteocalcin and osteopontin) in human normal osteoblasts, while they reduced intracellular reactive oxygen species production in macrophages. Furthermore, materials loaded with PPh showed antibiofilm properties against Gram positive and Gram negative bacteria. The results suggest that obtained materials represent potential multifunctional biomaterials for bone tissue engineering with a wide range of tunable properties.
