Szczegóły publikacji
Opis bibliograficzny
Microstructure and mechanical properties of PU/PLDL sponges intended for grafting injured spinal cord / Anna LIS-BARTOS, Dariusz Szarek, Małgorzata KROK-BORKOWICZ, Krzysztof Marycz, Włodzimierz Jarmundowicz, Jadwiga LASKA // Polymers [Dokument elektroniczny]. — Czasopismo elektroniczne ; ISSN 2073-4360. — 2020 — vol. 12 iss. 11, art. no. 2693, s. 1-17. — Wymagania systemowe: Adobe Reader. — Bibliogr. s. 14-17, Abstr. — Publikacja dostępna online od: 2020-11-16
Autorzy (6)
- AGHLis-Bartos Anna
- Szarek Dariusz
- AGHKrok-Borkowicz Małgorzata
- Marycz Krzysztof
- Jarmundowicz Włodzimierz
- AGHLaska Jadwiga
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 131072 |
|---|---|
| Data dodania do BaDAP | 2020-11-24 |
| Tekst źródłowy | URL |
| DOI | 10.3390/polym12112693 |
| Rok publikacji | 2020 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Polymers (Basel) |
Abstract
Highly porous, elastic, and degradable polyurethane and polyurethane/polylactide (PU/PLDL) sponges, in various shapes and sizes, with open interconnected pores, and porosity up to 90% have been manufactured. They have been intended for gap filling in the injured spinal cord. The porosity of the sponges depended on the content of polylactide, i.e., it decreased with the increase of polylactide content. The rise of polylactide content caused an increase of Young modulus and rigidity as well as a more complex morphology of the polyurethane/polylactide blends. The mechanical properties, in vitro toxicity, and degradation in artificial cerebrospinal fluid were tested. Sponges underwent continuous degradation with varying degradation rates depending on the polymer composition. In vitro cell studies with fibroblast cultures proved the biocompatibility of the polymers. Based on the obtained results, the designed PU/PLDL sponges appeared to be promising candidates for bridging gaps within injured spinal cord in further in vitro and in vivo studies.