Szczegóły publikacji
Opis bibliograficzny
Omalizumab may decrease the thickness of the reticular basement membrane and fibronectin deposit in the bronchial mucosa of severe allergic asthmatics / Weronika Zastrzeżyńska, Marek Przybyszowski, Stanisława Bazan-Socha, Agnieszka Gawlewicz-Mroczka, Piotr Sadowski, Krzysztof Okoń, Bogdan Jakieła, Hanna Plutecka, Adam ĆMIEL, Krzysztof Sładek, Jacek Musiał, Jerzy Soja // The Journal of Asthma ; ISSN 0277-0903. — 2020 — vol. 57 iss. 5, s. 468–477. — Bibliogr. s. 475–477, Abstr. — Publikacja dostępna online od: 2019-03-23
Autorzy (12)
- Zastrzeżyńska Weronika
- Przybyszowski Marek
- Bazan-Socha Stanisław
- Gawlewicz-Mroczka Agnieszka
- Sadowski Piotr
- Okoń Krzysztof
- Jakieła Bogdan
- Plutecka Hanna
- AGHĆmiel Adam
- Sładek Krzysztof
- Musiał Jacek
- Soja Jerzy
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 128955 |
|---|---|
| Data dodania do BaDAP | 2020-06-12 |
| DOI | 10.1080/02770903.2019.1585872 |
| Rok publikacji | 2020 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | The Journal of Asthma |
Abstract
Introduction: Immunoglobulin E is an important modulator of the inflammatory reaction in allergic asthma. It also contributes to airway remodeling in the course of the disease. The authors evaluated airway structural changes in severe allergic asthma during the omalizumab therapy. Patients and methods: The study included 13 patients with severe allergic asthma treated with omalizumab for at least one year. In each patient clinical, laboratory, and spirometry parameters were evaluated before and after the treatment. In addition, bronchoscopy with bronchial mucosa biopsy and bronchoalveolar lavage was performed. The basal lamina thickness, inflammatory cell infiltration, fibronectin, as well as type I and III collagen accumulation were assessed in bronchial mucosa specimens, together with the assessment of bronchoalveolar lavage cellularity. Results: The omalizumab therapy led to a decrease in the basal lamina thickness (p = 0.002), and to a reduction in fibronectin (p = 0.02), but not collagen deposits in the bronchial mucosa. The decrease in fibronectin accumulation was associated with an improvement in asthma control and quality of life (p = 0.01, both), and a diminished dose of systemic corticosteroids (p = 0.001). It was also associated with a tendency towards reduction of the eosinophil count in the peripheral blood, bronchoalveolar lavage fluid, and bronchial mucosa specimens. Conclusion: Our study has shown that omalizumab, effective in the treatment of severe allergic asthma, may also decrease unfavorable structural airway changes in allergic asthmatics, at least with respect to the fibronectin deposit and an increased thickness of the basal lamina. However, more extensive observational studies are needed to verify the above hypothesis.