Szczegóły publikacji
Opis bibliograficzny
Detection of legal highs in the urine of methadone-treated patient by LC‐MS / Krzysztof Łabuz, Piotr Adamowicz, Maria Kała, Krzysztof Pyrc, Edward Reszke, Przemysław MIELCZAREK, Jerzy SILBERRING, Marek SMOLUCH // Basic & Clinical Pharmacology & Toxicology ; ISSN 1742-7835. — 2019 — vol. 125 iss. 3, s. 253–258. — Bibliogr. s. 258, Abstr. — Publikacja dostępna online od: 2019-06-12. — P. Mielczarek - dod. afiliacja: Laboratory of Proteomics and Mass Spectrometry, Institute of Pharmacology, Polish Academy of Sciences, Krakow. — J. Silberring - Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland
Autorzy (8)
- Łabuz Krzysztof
- Adamowicz Piotr
- Kała Maria
- Pyrć Krzysztof
- Reszke Edward
- AGHMielczarek Przemysław
- AGHSilberring Jerzy
- AGHSmoluch Marek
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 123675 |
|---|---|
| Data dodania do BaDAP | 2019-10-03 |
| Tekst źródłowy | URL |
| DOI | 10.1111/bcpt.13270 |
| Rok publikacji | 2019 |
| Typ publikacji | przegląd |
| Otwarty dostęp |  |
| Creative Commons | |
| Czasopismo/seria | Basic & Clinical Pharmacology & Toxicology |
Abstract
Urine tests are the commonly accepted methods to control abstinence and adherence to treatment of patients who undergo methadone maintenance treatment (MMT). Depending on various national guidelines and accessibility of techniques, only selected psychoactive substances are routinely tested in urine of MMT patients. In general, they belong to the few groups of compounds: THC, cocaine, amphetamines, opiates, PCP and benzodiazepines. It is, however, well known that patients enrolled in such replacement programmes take psychoactive substances that are not routinely detected by the toxicology laboratories, to escape unexpected tests. Here, we report semiquantitative detection of legal highs taken by the MMT patient, using high-pressure liquid chromatography coupled to the flowing atmospheric pressure afterglow ion source (LC-FAPA-MS). To demonstrate effectivity of this technique, the data were confirmed by quantitative analysis using LC-ESI-MS/MS. In the analysed sample of MMT patient, a mixture of psychoactive compounds was found, namely 3-MMC (3-methylmethcathinone), pentedrone and methcathinone and determined at the concentrations of 670; 50 and 0.2 µg/mL, respectively. Such fast analytical technique may be useful for the efficient control of substances taken intentionally by MMT patients. © 2019 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)
