Szczegóły publikacji
Opis bibliograficzny
Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity / Timothy E. L. Douglas, Michał DZIADEK, [et al.], Katarzyna CHOLEWA-KOWALSKA, [et al.] // Carbohydrate Polymers ; ISSN 0144-8617. — 2019 — vol. 205, s. 427–436. — Bibliogr. s. 435–436, Abstr. — Publikacja dostępna online od: 2018-10-26. — M. Dziadek – dod. afilicja: Lancaster University, United Kingdom
Autorzy (14)
- Douglas Timothy E. L.
- AGHDziadek Michał
- Schietse Josefien
- Boone Matthieu
- Declercq Heidi A.
- Coenye Tom
- Vanhoorne Valérie
- Vervaet Chris
- Balcaen Lieve
- Buchweitz Maria
- Vanhaecke Frank
- Assche Frederic van
- AGHCholewa-Kowalska Katarzyna
- Skirtach Andre G.
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 117942 |
|---|---|
| Data dodania do BaDAP | 2018-11-28 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.carbpol.2018.10.061 |
| Rok publikacji | 2019 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Carbohydrate Polymers |
Abstract
The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gel-derived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a relatively simple mixing technique, using 20% w/v BG particles of two different sizes (2.5 and <45 μm). Smaller particles accelerated pectin gelation slightly faster than bigger ones, which appears to result from the higher rate of Ca2+ ion release. μCT showed inhomogeneous distribution of the BG particles within the hydrogels. All composite hydrogels exhibited strong antibacterial activity against methicilin-resistant Staphylococcus aureus. The mineralization process of pectin-BG composite hydrogels occurred upon incubation in simulated body fluid for 28 days. In vitro studies demonstrated cytocompatibility of composite hydrogels with MC3T3-E1 osteoblastic cells.
