Szczegóły publikacji
Opis bibliograficzny
Silicone-stabilized liposomes as a possible novel nanostructural drug carrier / Joanna Lewandowska-Łańcucka, Katarzyna Mystek, Adriana Gilarska, Kamil Kamiński, Marek Romek, Bogdan Sulikowski, Maria Nowakowska // Colloids and Surfaces. B, Biointerfaces ; ISSN 0927-7765. — 2016 — vol. 143, s. 359–370. — Bibliogr. s. 369–370, Abstr. — Publikacja dostępna online od: 2016-03-19. — A. Gilarska - afiliacja: Jagiellonian University
Autorzy (7)
- Lewandowska-Łańcucka Joanna
- Mystek Katarzyna
- Gilarska Adriana
- Kamiński Kamil
- Romek Marek
- Sulikowski Bogdan
- Nowakowska Maria
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 114985 |
|---|---|
| Data dodania do BaDAP | 2018-07-16 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.colsurfb.2016.03.057 |
| Rok publikacji | 2016 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Colloids and Surfaces, B, Biointerfaces |
Abstract
Development of silicone stabilized liposomes which can serve as novel drug nanocarriers is presented. Silicone precursor 1,3,5,7-tetramethylcyclotetrasiloxane (D-4(H)) was introduced into the bilayer of the cationic liposomes prepared from egg yolk phosphatidylocholine (PC) and double-tailed dimethyldioctadecylammonium bromide (DODAB). The silicone material was created inside of the liposomal bilayer in the base-catalyzed polycondensation process of the D-4(H) what was confirmed employing Si-29 solid-state MAS NMR and FTIR measurements. Surfactant lysis experiments revealed that resulted systems can be effectively stabilized. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements demonstrated that the silicone-stabilized liposomes have typical lipid vesicle's morphology and mean hydrodynamic diameters in the range of about 110 nm. They have considerably lower tendency for aggregation than the pristine liposomes. The permeability of vesicles can be tuned by introducing various amounts of silicone precursor into the liposome bilayer, as confirmed in calcein-release studies. The effect of fetal bovine serum (FBS) on the stability of liposomes was also tested in in vitro studies. Biological studies revealed that resulted liposomes can be considered as possible drug nanocarriers because they are not toxic to human skin fibroblasts (HSFs) and mouse embryonic fibroblasts (MEFs). (C) 2016 Elsevier B.V. All rights reserved.
