Szczegóły publikacji
Opis bibliograficzny
Gentamicin-loaded polysaccharide membranes for prevention and treatment of post-operative wound infections in the skeletal system / Urszula CIBOR, Małgorzata KROK-BORKOWICZ, Monika Brzychczy-Włoch, Łucja RUMIAN, Krzysztof PIETRYGA, Dominika Kulig, Wojciech Chrzanowski, Elżbieta PAMUŁA // Pharmaceutical Research ; ISSN 0724-8741. — 2017 — vol. 34 iss. 10, s. 2075–2083. — Bibliogr. s. 2082–2083, Abstr. — Publikacja dostępna online od: 2017-06-21
Autorzy (8)
- AGHCibor Urszula
- AGHKrok-Borkowicz Małgorzata
- Brzychczy-Włoch Monika
- AGHRumian Łucja Dobromiła
- AGHPietryga Krzysztof
- AGHKulig Dominika
- Chrzanowski Wojciech
- AGHPamuła Elżbieta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 110192 |
|---|---|
| Data dodania do BaDAP | 2017-12-10 |
| Tekst źródłowy | URL |
| DOI | 10.1007/s11095-017-2212-5 |
| Rok publikacji | 2017 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Pharmaceutical Research |
Abstract
To develop polysaccharide-based membranes that allow controlled and localized delivery of gentamicin for the treatment of post-operative bone infections. Membranes made of gellan gum (GUM), sodium alginate (ALG), GUM and ALG crosslinked with calcium ions (GUM + Ca and ALG + Ca, respectively) as well as reference collagen (COL) were produced by freeze-drying. Mechanical properties, drug release, antimicrobial activity and cytocompatibility of the membranes were assessed. The most appropriate handling and mechanical properties (Young's modulus, E = 92 +/- 4 MPa and breaking force, F (MAX) = 2.6 +/- 0.1 N) had GUM + Ca membrane. In contrast, COL membrane showed F (MAX) = 0.14 +/- 0.02 N, E = 1.0 +/- 0.3 MPa and was deemed to be unsuitable for antibiotic delivery. The pharmacokinetic data demonstrated a uniform and sustainable delivery of gentamicin from GUM + Ca (44.4 +/- 1.3% within 3 weeks), while for COL, ALG and ALG + Ca membranes the most of the drug was released within 24 h (55.3 +/- 1.9%, 52.5 +/- 1.5% and 37.5 +/- 1.8%, respectively). Antimicrobial activity against S. aureus and S. epidermidis was confirmed for all the membranes. GUM + Ca and COL membranes supported osteoblasts growth, whereas on ALG and ALG + Ca membranes cell growth was reduced. GUM + Ca membrane holds promise for effective treatment of bone infections thanks to favorable pharmacokinetics, bactericidal activity, cytocompatibility and good mechanical properties.
