Szczegóły publikacji
Opis bibliograficzny
ADX-47273, a mGlu5 receptor positive allosteric modulator, attenuates deficits in cognitive flexibility induced by withdrawal from 'binge-like' ethanol exposure in rats / Marta Marszałek-Grabska, Ewa Gibuła-Bruzda, Anna BODZOŃ-KUŁAKOWSKA, Piotr SUDER, Kinga Gaweł, Sylwia Talarek, Joanna Listos, Ewa Kędzierska, Wojciech Danysz, Jolanta H. Kotlińska // Behavioural Brain Research ; ISSN 0166-4328. — 2018 — vol. 338, s. 9–16. — Bibliogr. s. 14–16, Abstr. — Publikacja dostępna online od: 2017-10-10
Autorzy (10)
- Marszałek-Grabska Marta
- Gibuła-Bruzda Ewa
- AGHBodzoń-Kułakowska Anna
- AGHSuder Piotr
- Gaweł K.
- Talarek Sylwia
- Listos Joanna
- Kędzierska Ewa
- Danysz Wojciech
- Kotlińska Jolanta Helena
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 109698 |
|---|---|
| Data dodania do BaDAP | 2017-12-15 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.bbr.2017.10.007 |
| Rok publikacji | 2018 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Behavioural Brain Research |
Abstract
Repeated exposure to and withdrawal from ethanol induces deficits in spatial reversal learning. Data indicate that metabotropic glutamate 5 (mGlu5) receptors are implicated in synaptic plasticity and learning and memory. These receptors functionally interact with N-methyl-d-aspartate (NMDA) receptors, and activation of one type results in the activation of the other. We examined whether (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-piperidin-1-yl (ADX-47273), a positive allosteric modulator (PAM) of mGlu5 receptor, attenuates deficits in reversal learning induced by withdrawal (11-13 days) from ‘binge-like’ ethanol input (5.0 g/kg, i.g. for 5 days) in the Barnes maze (a spatial learning) task in rats. We additionally examined the effects of ADX-47273 on the expression of the NMDA receptors subunit, GluN2B, in the hippocampus and prefrontal cortex, on the 13th day of ethanol withdrawal. Herein, withdrawal from repeated ethanol administration impaired reversal learning, but not the probe trial. Moreover, ADX-47273 (30 mg/kg, i.p.) given prior to the first reversal learning trial for 3 days in the Barnes maze, significantly enhanced performance in the ethanol-treated group. The 13th day of ethanol abstinence decreased the expression of the GluN2 B subunit in the selected brain regions, but ADX-47273 administration increased it. In conclusion, positive allosteric modulation of mGlu5 receptors recovered spatial reversal learning impairment induced by withdrawal from ‘binge-like’ ethanol exposure. Such effect seems to be correlated with the mGlu5 receptors mediated potentiation of GluN2B-NMDA receptor mediated responses in the hippocampus and prefrontal cortex. Thus, our results emphasize the role of mGlu5 receptor PAM in the adaptive learning impaired by ethanol exposure.
