Szczegóły publikacji
Opis bibliograficzny
Sensitivity analysis of two-compartment model parameters for extracorporeal liver therapy purposes / Aleksandra JUNG // W: Recent developments and achievements in biocybernetics and biomedical engineering : proceedings of the 20th Polish Conference on Biocybernetics and Biomedical Engineering, Kraków, Poland, September 20-22, 2017 / eds. Piotr Augustyniak, Roman Maniewski, Ryszard Tadeusiewicz. — [Cham] : Springer International Publishing, cop. 2018. — (Advances in Intelligent Systems and Computing ; ISSN 2194-5357 ; vol. 647). — ISBN: 978-3-319-66904-5; e-ISBN: 978-3-319-66905-2. — S. 257–263. — Bibliogr. s. 263, Abstr.
Autor
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 109391 |
|---|---|
| Data dodania do BaDAP | 2017-10-24 |
| DOI | 10.1007/978-3-319-66905-2_22 |
| Rok publikacji | 2018 |
| Typ publikacji | materiały konferencyjne (aut.) |
| Otwarty dostęp |  |
| Wydawca | Springer |
| Konferencja | 20th Polish Conference on Biocybernetics and Biomedical Engineering |
| Czasopismo/seria | Advances in Intelligent Systems and Computing |
Abstract
Time-stable volume two compartment conjugated bilirubin (cb) kinetics model was applied for sensitivity analysis. Model parameters variation influence on time course of cb concentration was determined. The analysis was performed for central and peripheral compartment during and between extracorporeal treatments. The analyzed model parameters were bilirubin generation G, volume V and intercompartmental clearance $$K:{pc}$$. Sensitivity with respect to G had a maximum at the end of the observed period of 24 h, while the sensitivities with respect to V and $$K:{pc}$$ reached their maxima during the treatment time. Sensitivity with respect to G was negligible at the beginning of the treatment and increased almost linearly after the treatment. It was similar for the central and peripheral output. Parameter V affected cb concentration the most strongly during the treatment, the sensitivity was lower for overhydrated patients. After the treatment sensitivity of V decreased almost linearly. The sensitivity with respect to $$K:{pc}$$ was low and even negative. Summarizing, the analysis demonstrated that cb concentration was highly sensitive to G and V whereas it was influenced by $$K:{pc}$$ to a much lesser extent. Sensitivity analysis indicates that parameters G and V may be estimated with high accuracy from cb concentration measurements for most patients but identification process must be provided more carefully for overhydrated patients. $$K:{pc}$$ is estimated less accurately, similarly to hemodialysis models. The accuracy of the parameter estimation may be improved by selecting the sampling time individually for each patient near the peak values of the sensitivity. © 2018, Springer International Publishing AG.
