Szczegóły publikacji
Opis bibliograficzny
Evaluation on antibacterial activity and cytocompatibility of $\alpha-TCP$ based bone cements with silver-doped hydroxyapatite and $CaCO_{3}$ / Dominika SIEK, Anna ŚLÓSARCZYK, Agata Przekora, Anna Belcarz, Aneta ZIMA, Grażyna Ginalska, Joanna CZECHOWSKA // Ceramics International ; ISSN 0272-8842. — Tytuł poprz.: Ceramurgia International ; ISSN: 0390-5519. — 2017 — vol. 43 iss. 16, s. 13997–14007. — Bibliogr. s. 14006–14007, Abstr. — Publikacja dostępna online od: 2017-07-18
Autorzy (7)
- AGHSiek Dominika
- AGHŚlósarczyk Anna
- Przekora Agata
- Belcarz Anna
- AGHZima Aneta
- Ginalska Grażyna
- AGHCzechowska Joanna
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 108355 |
|---|---|
| Data dodania do BaDAP | 2017-09-18 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.ceramint.2017.07.131 |
| Rok publikacji | 2017 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Ceramics International |
Abstract
The implant-related infections are a severe problem in orthopedic surgery. In this work, bone cements based on α-TCP, silver doped hydroxyapatite and calcite were examined. Developed bioactive materials revealed good surgical handiness and appropriate setting times allowing for their application. In order to assess antibacterial properties, two independent experiments (test imitating in vivo conditions and test of cumulative extraction) were used. It was found that bone cement matrix do not impede the Ag+ release from the Ag-HA agglomerates. Materials showed mild antibacterial activity which depended on the kind of bacterial strain and the type of test. Presence of silver in the tested materials increased the antibacterial activity in the extracts only for E. coli strain and the effect was transient. In the case of Gram-positive strains (S. aureus and S. epidermidis), antibacterial activity was most probably connected with the properties of cement material, not with the content of silver. Observed reduction of osteoblast viability in vitro resulted from the synergic effect: decrease in concentrations of Ca2+, Mg2+, and PO43- ions in the culture medium and the presence of silver ions.
