Szczegóły publikacji
Opis bibliograficzny
Ceramic scaffolds with immobilized vancomycin-loaded poly(lactide-co-glycolide) microparticles for bone defects treatment / Łucja RUMIAN, Hanna Tiainen, Urszula CIBOR, Małgorzata KROK-BORKOWICZ, Monika Brzychczy-Włoch, Håvard J. Haugen, Elżbieta PAMUŁA // Materials Letters ; ISSN 0167-577X. — 2017 — vol. 190, s. 67–70. — Bibliogr. s. 70, Abstr. — Publikacja dostępna online od: 2016-12-30
Autorzy (7)
- AGHRumian Łucja Dobromiła
- Tiainen Hanna
- AGHCibor Urszula
- AGHKrok-Borkowicz Małgorzata
- Brzychczy-Włoch Monika
- Haugen Håvard Jostein
- AGHPamuła Elżbieta
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 104670 |
|---|---|
| Data dodania do BaDAP | 2017-04-06 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.matlet.2016.12.113 |
| Rok publikacji | 2017 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Materials Letters |
Abstract
Three-dimensional scaffolds are often used to support healing process for bone defects reconstruction. Unfortunately a common occurrence of post-implantation infections results in their high failure rate. Thus we propose new TiO2 scaffolds that combine mechanical support and controlled antibiotics release to assure bactericidal properties. Poly(L-lactide-co-glycolide) microparticles containing vancomycin were successfully immobilized on the scaffolds pore walls with the use of cross-linked sodium alginate. Prolonged drug release was achieved from such systems with initial burst release of 22% within 8 h, which falls within “decisive period” after surgical procedures of effective infection control. Antimicrobial properties of drug released from the systems against Staphylococcus spp. as well as cytocompatibility in contact with osteoblast-like cells (MG-63) were proven. Hence such scaffolds may be promising for infection prevention and bone tissue defects treatment. © 2016 Elsevier B.V.