Szczegóły publikacji
Opis bibliograficzny
Biocompatible and fluorescent superparamagnetic iron oxide nanoparticles with superior magnetic properties coated with charged polysaccharide derivatives / Dorota LACHOWICZ, Agnieszka Szpak, Katarzyna E. Malek-Zietek, Mariusz Kepczynski, Robert N. Muller, Sophie Laurent, Maria Nowakowska, Szczepan Zapotoczny // Colloids and Surfaces . B, Biointerfaces ; ISSN 0927-7765. — 2017 — vol. 150, s. 402–407. — Bibliogr. s. 407, Abstr. — Publikacja dostępna online od: 2016-11-02. — D. Lachowicz - dod. afiliacja: Faculty of Chemistry, Jagiellonian University
Autorzy (8)
- AGHLachowicz Dorota
- Szpak Agnieszka
- Malek-Zietek Katarzyna E.
- Kępczyński Mariusz
- Muller Robert N.
- Laurent Sophie
- Nowakowska Maria
- Zapotoczny Szczepan
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 104583 |
|---|---|
| Data dodania do BaDAP | 2017-05-08 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.colsurfb.2016.11.003 |
| Rok publikacji | 2017 |
| Typ publikacji | artykuł w czasopiśmie |
| Otwarty dostęp |  |
| Czasopismo/seria | Colloids and Surfaces, B, Biointerfaces |
Abstract
Syntheses and characterizations of biocompatible superparamagnetic iron oxide nanoparticles with embedded curcumin and coated with ultrathin layer of hyaluronic acid-curcumin (HA-Cur) conjugate have been reported. Zeta potential measurements confirmed effective coating of native iron oxide nanoparticles stabilized by cationic derivative of chitosan (SPION-CCh) with the synthesized HA-Cur conjugate. Both SPIONs with embedded curcumin and the ones coated with HA-Cur (SPION-CCh/HA-Cur) revealed desired magnetic characteristics while fluorescent properties were much better for the coated nanoparticles. SPION-CCh/HA-Cur nanoparticles were shown to be very promising candidates for T2 MRI contrast agents as they can easily penetrate cell membrane and their relaxivity is exceptionally high (ca. 470 mM−1 s−1). They may be also tracked using confocal fluorescence microscopy due to the presence of fluorescent curcumin in the coating. In vitro studies indicated that the obtained SPIONs-CCh/HA-Cur were non-toxic for EA.hy926 endothelial cells.
