Szczegóły publikacji
Opis bibliograficzny
Interaction of bombesin and its fragments with gold nanoparticles analyzed using surface-enhanced Raman spectroscopy / Agnieszka TĄTA, Aleksandra SZKUDLAREK, Younkyoo Kim, Edyta PRONIEWICZ // Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy ; ISSN 1386-1425. — 2017 — vol. 173, s. 251–256. — Bibliogr. s. 256, Abstr. — Publikacja dostępna online od: 2016-09-20
Autorzy (4)
Słowa kluczowe
Dane bibliometryczne
| ID BaDAP | 100627 |
|---|---|
| Data dodania do BaDAP | 2016-09-29 |
| Tekst źródłowy | URL |
| DOI | 10.1016/j.saa.2016.09.024 |
| Rok publikacji | 2017 |
| Typ publikacji | przegląd |
| Otwarty dostęp |  |
| Czasopismo/seria | Spectrochimica Acta, Part A, Molecular and Biomolecular Spectroscopy |
Abstract
This work demonstrates the application of commercially available stable surface composed of gold nanograins with diameters ranging from 70 to 226 nm deposited onto silicon wafer for surface-enhanced Raman scattering investigations of biologically active compounds, such as bombesin (BN) and its fragments. BN is an important neurotransmitter involved in a complex signaling pathways and biological responses; for instance, hypertensive action, contractive on uterus, colon or ileum, locomotor activity, stimulation of gastric and insulin secretion as well as growth promotion of various tumor cell lines, including: lung, prostate, stomach, colon, and breast. It has also been shown that 8–14 BN C-terminal fragment partially retains the biological activity of BN. The SERS results for BN and its fragment demonstrated that (1) three amino acids from these peptides sequence; i.e., l-histidine, l-methionine, and l-tryptophan, are involved in the interaction with gold coated silicon wafer and (2) the strength of these interactions depends upon the aforementioned amino acids position in the peptide sequence.
