Szczegóły publikacji

Opis bibliograficzny

Protein-stabilized bimetallic Au/Ag nanoclusters as fluorescent reporters: Synthesis, characterization and their interactions with biocolloids / Árpád Turcsányi, Ditta Ungor, Marek WOJNICKI, Edit Csapó // Journal of Molecular Liquids ; ISSN 0167-7322. — 2023 — vol. 370 art. no. 121002, s. 1–9. — Bibliogr. s. 8–9, Abstr. — Publikacja dostępna online od: 2022-12-09


Autorzy (4)


Słowa kluczowe

gold-silverbiolabelingdrug carrier particlesfluorescencebimetallic nanoclusters

Dane bibliometryczne

ID BaDAP144322
Data dodania do BaDAP2023-01-02
Tekst źródłowyURL
DOI10.1016/j.molliq.2022.121002
Rok publikacji2023
Typ publikacjiartykuł w czasopiśmie
Otwarty dostęptak
Creative Commons
Czasopismo/seriaJournal of Molecular Liquids

Abstract

Fabrication protocol of bovine serum albumin-(BSA) and lysozyme-(LYZ) stabilized gold/silver bimetallic nanoclusters (Au/Ag NCs) have been reported via optimization of the protein/metal ion ratios, metal concentration, pH and incubation time. No other reducing and stabilizing compounds were used to produce these nanoclusters at room temperature. Incorporation of small quantities of silver (∼3–10 w%) into the gold core substantially changed the optical features such as the enhancing of the quantum yield and blue shifting of the emission wavelength compared to their purely gold-based derivatives. Applicability of the BSA- and LYZ-directed Au/Ag NCs having intense fluorescence at above ∼ 600 nm as potential fluorescent reporters (FRs) has been studied by examining their interactions with chitosan/hyaluronic acid (Chit/HyA)-based colloidal drug delivery particles. It was found that, in contrast to the monometallic derivatives, our bimetallic NCs, prepared at room temperature and stabilized with larger amounts of proteins, exhibit a much higher degree of stability during interaction with biocolloids. The results are confirmed by fluorescence measurements in addition to light scattering studies, since the aggregation-induced emission is not observed dominantly, as clearly confirmed for Au-based NCs. Utilizing the alloying process and the milder preparation conditions can be a promising route to the synthesis of noble metal NCs-based FRs in biomedical field.

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